Long term suppressive acyclovir (ACV) reduces VZV disease and ACV-resistant HSV after HCT
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چکیده
منابع مشابه
O and [ { Hg ( ACV ) Cl 2 } x ] . Recognition of acyclovir by Ni – ACV
The monomeric [M(ACV)2(H2O)4]Cl2?2ACV (M = Ni 1 or Co 2), [Zn(ACV)Cl2(H2O)] 3 and the polymeric [Cd(ACV)Cl2]?H2O 4 [ACV = acyclovir = 9-(2-hydroxymethoxymethyl)guanine] complex have been prepared and characterised by X-ray diffraction and IR data; H and C NMR have been used to interpret the structural characteristics of the complexes in solution. Compounds 1 and 2 exist as octahedral complexes ...
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Following initial infection, herpesviruses retreat into a permanent latent state with periodic reactivation resulting in an enhanced likelihood of transmission and clinical disease. The nucleoside analogue acyclovir reduces clinical symptoms of the three human alpha herpesviruses, HSV-1, HSV-2, and VZV. Long-term administration of acyclovir (ACV) can reduce the frequency and severity of reactiv...
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PURPOSE Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant (ACV(R)) HSV-1 and clinical consequences thereof in patients with recurrent HSV-1 keratitis (rHK). METHODS F...
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Background: Acyclovir (ACV) is a synthetic purine nucleoside analog drived from guanosine. ACV possesses antiviral activity against Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2 ), Varicella Zoster virus (VZV) , Epstein Barr virus (EBV) and Cytomegalovirus (CMV). ACV exert its effects by interfering with DNA synthesis,thus inhibiting viral replication. ACV is khown to be toxic to gonads,t...
متن کاملSurvey of resistance of herpes simplex virus to acyclovir in northwest England.
Acyclovir (ACV) has been used for more than 15 years in the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) disease. The present survey was undertaken to assess the level of ACV resistance in the population. More than 2,000 HSV isolates from both immunocompetent and immunocompromised patients in northwest England were collected over a 2-year period and tested for sensi...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2006
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2005.11.430